羟甲芬太尼是一种强效镇痛药，本实验采用３种动物、３种药物精神依赖性评价方法对其精神依赖性潜力进行系统评价，结果表明羟甲芬太尼存在着一定的精神依赖性潜力，但等效剂量的羟甲芬太尼的精神依赖性潜力低于吗啡，同时对其依赖性机理进行初步探讨推测其药物强化效应可能是通过阿片μ－受体起作用的。 Hydroxymetazidine is a potent analgesic. In this study, we evaluated the psychic dependent potential of three kinds of animals and three drug-based mental dependence methods. The results showed that there was a certain Mental dependence potential, but the equivalent dose of hydroxymethyl fentanyl spiritual dependence potential is lower than that of morphine, and its dependence on the mechanism of a preliminary study speculated that the drug-enhancing effect may be through opiate μ-receptor role.