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目的探讨端粒酶与宫颈炎和宫颈癌变发生的相关性。方法对97例慢性宫颈炎、31例宫颈浸润性鳞癌(ISCC)标本采用免疫组化S-P法检测端粒酶活性。结果端粒酶在宫颈慢性炎中无表达,在ISCC中阳性率为82.47%,呈高表达。结论端粒酶活性的表达与宫颈炎、宫颈癌的发生密切相关。
Objective To investigate the correlation between telomerase and cervicitis and cervical carcinogenesis. Methods The telomerase activity of 97 cases of chronic cervicitis and 31 cases of invasive cervical squamous cell carcinoma (ISCC) was detected by immunohistochemical S-P method. Results There was no expression of telomerase in chronic cervicitis. The positive rate in ISCC was 82.47%, which was highly expressed. Conclusion The expression of telomerase activity is closely related to the occurrence of cervicitis and cervical cancer.