目的 :了解非甾体消炎药及某些抗生素引起消化道粘膜损害的情况。方法 :跟踪观察 1 1例服克林霉素、3例服泰诺、4例服感康后的消化道症状、内镜下消化道粘膜的改变及病理改变。结果 :药物性急性消化道粘膜损害主要表现为食管、胃、末端回肠粘膜糜烂、溃疡及出血。药物性消化道损害大多与个体对药物反应有关 ,也不排除与药物本身的毒副作用、酸碱度及抗原性有关。结论 :对药物引起的消化道粘膜损害 ,要尽早发现 ,立即停药 ,并注意预防。 Objective: To understand the non-steroidal anti-inflammatory drugs and some antibiotics caused gastrointestinal mucosal damage. Methods: Follow-up observation was performed on 11 cases of clindamycin, 3 cases of Tylenol, 4 cases of Yikangkang after gastrointestinal symptoms, endoscopic mucosal changes and pathological changes. Results: Drug-induced acute gastrointestinal mucosal damage mainly manifested as esophageal, gastric, terminal ileal mucosal erosion, ulcers and bleeding. Most of the drug-induced gastrointestinal damage and the individual’s response to the drug, does not rule out the drug itself side effects, pH and antigenicity. Conclusion: Drug-induced gastrointestinal mucosal damage should be found as soon as possible, immediately stop the medication, and pay attention to prevention.