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目的了解不同剂量青蒿琥酯对食蟹猴疟原虫孢子增殖的影响。方法首剂药量加倍 ,随后24 ,48 ,72和96小时给实验猴各肌注一次 ,疗程5天 ,总剂量分别为15.0mg/kg、7.2mg/kg、3.6mg/kg、1.8mg/kg;在给药前及给药后6、12、24、30、36、48、54、60、72、84和108小时各用一批大劣按蚊叮咬实验猴 ,叮咬后第9天解剖蚊胃 ,第13天解剖涎腺。结果在1.8～15mg/kg剂量范围内均能阻断食蟹猴疟原虫孢子增殖。结论较低剂量青蒿琥酯亦能阻断孢子增殖 ,且随药物浓度增加 ,阻断速度会相应增快
Objective To investigate the effects of different doses of artesunate on the sporulation of Plasmodium crocodynsi. Methods The dose of the first dose was doubled, and each monkeys were injected intramuscularly once every 24, 48, 72 and 96 hours for 5 days. The total dose was 15.0 mg / kg, 7.2 mg / kg, 3.6 mg / kg, 1.8 mg / kg; An experimental group of monkeys were bred with anopheles sinensis at 6, 12, 24, 30, 36, 48, 54, 60, 72, 84 and 108 hours after dosing and 9 days after bite Mosquito stomach, the first 13 days dissection salivary glands. Results In 1.8 ~ 15mg / kg dose range can be blocked cynomolgous Plasmodium sporozoites. Conclusions Lower doses of artesunate can also inhibit the spore proliferation, and with the increase of drug concentration, the blocking speed will be correspondingly increased