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目的:探讨南方人群中鼻咽癌(NPC)易感性与HLA多态性之间的关联。方法:应用聚合酶链反应/序列特异性引物(PCR-SSP)方法对35例NPC患者及60例正常对照进行HLA-A、HLA-B及DRB1基因分型。结果:NPC患者的HLA-A*02、HLA-B*58及HLA-DRB1*03基因位点的频率高于正常对照组,HLA-B*40基因位点的频率低于正常对照组。结论:HLA-A*02、HLA-B*58及HLA-DRB1*03可能是NPC的易感性基因,HLA-B*40可能是NPC的保护性基因。
Objective: To investigate the association between NPC susceptibility and HLA polymorphism in southern populations. Methods: HLA-A, HLA-B and DRB1 genotypes were detected in 35 NPC patients and 60 normal controls by polymerase chain reaction / sequence specific primer (PCR-SSP). Results: The frequencies of HLA-A * 02, HLA-B * 58 and HLA-DRB1 * 03 loci in NPC patients were higher than those in normal controls. The frequencies of HLA-B * 40 loci were lower than those in normal controls. Conclusion: HLA-A * 02, HLA-B * 58 and HLA-DRB1 * 03 may be NPC susceptibility genes. HLA-B * 40 may be a NPC protective gene.