博来霉素(BLM)是梅泽等从轮枝链霉菌(Str vertieillus)发酵液里发现的一族糖肽类抗肿瘤抗生素,能与铜离子形成整合物,组份之间的区别在于共有的线状结构 C端的氨基侧链。BLM 已用于临床,可治疗何杰金氏淋巴瘤,皮肤、头和颈部癌,以及睾丸瘤,常与放射治疗或其他药物的化疗联合使用。 Bleomycin (BLM) is a family of glycopeptide antitumor antibiotics discovered by Meze et al. From the fermentation broth of Streptieces fulgidus and capable of forming complexes with copper ions. The difference between the components is that they are common Amino side chain at C-terminal of linear structure. BLM has been used clinically to treat Hodgkin’s lymphoma, skin, head and neck cancers, and testicular tumors, often in combination with radiotherapy or other drug chemotherapies.