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由金属酞菁(主要是铁酞菁)、抗坏血酸、氧构成的单加氧酶P-450新模拟体系,对苯的羟化具有显著的催化活性。实验证明,含氮大环配位体——酞菁和一般的含氮配位体相比,对中心金属离子的活化作用特别明显。根据电子光谱数据,发现由Fe~(2+)、抗坏血酸与适当配位体形成中间三元络合物是氧活化的重要步骤。据此,对其中抗坏血酸的作用以及形成中间双氧络合物的可能途径作了理论上和实验上的阐明,并在此基础上提出了苯羟化的作用机理。
The new simulation system of monooxygenase P-450 composed of metal phthalocyanine (mainly iron phthalocyanine), ascorbic acid and oxygen has significant catalytic activity for the hydroxylation of benzene. Experiments show that, nitrogen-containing macrocyclic ligand - phthalocyanine and the general nitrogen-containing ligand, the activation of the central metal ion is particularly evident. According to the electron spectroscopy data, it was found that the formation of intermediate ternary complexes with Fe2 +, ascorbic acid and appropriate ligands is an important step in the activation of oxygen. Based on this, the theoretical and experimental elucidation of the role of ascorbic acid and the possible ways of forming intermediate dioxygen complexes are proposed. On this basis, the mechanism of benzene hydroxylation is proposed.