Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity

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Fourteen new geranyl phenyl ethers(1-14)along with three known compounds(15-17)were isolated from Illicium micranthum,and their structures were elucidated by comprehensive spectroscopic methods.Illimicranins A-H(1-8)were character-ized as geranyl vanillin ethers,while 9 and 10 were dimethyl acetal derivatives.Illimicranins I and J(11 and 12)were rare geranyl isoeugenol ethers.Illimicranins K and L(13 and 14)represented the first example of geranyl guaiacylacetone ether and geranyl zinger-one ether,respectively.Compounds 1,2 and 15 exhibited anti-HBV(hepatitis B virus)activity against HBsAg(hepatitis B surface an-tigen)and HBeAg(hepatitis B e antigen)secretion,and HBV DNA replication.
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