苯妥因(PHT)和卡马西平(CBZ)是治疗部分性和全身性强直—阵挛发作的一线药物。两药具有类似的抗痫作用和毒性。临床上常将两药合用于难治性痫性发作。为了对这种联合用药作出客观的评价,作者将两药用于小鼠实验,以观察其单用和合用时的抗痫作用和毒性,同时测定血浆和脑的药物浓度,以分析其药效学相互作用的特性。 用雌性刚成熟的小鼠作实验。在剂量反应研究中,以最大电休克(MES)引起的 Phenytoin (PHT) and carbamazepine (CBZ) are first-line drugs for the treatment of partial and generalized tonic-clonic seizures. Both drugs have similar anti-epileptic effects and toxicity. Clinically, the two drugs are often used in refractory seizures. In order to make an objective evaluation of this combination, the authors used the two drugs in mouse experiments to observe their anti-epileptic effects and toxicity when used alone and in combination with plasma and brain drug concentrations to analyze their pharmacodynamics The nature of the interaction. Experiments were performed with female, freshly mature mice. In dose-response studies, the maximum electrical shock (MES) caused