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无创伤性产前诊断方法,主要指通过非创伤性手段对胎儿是否患有某种遗传病或先天缺陷在出生前作出准确判断的方法。广义上讲,产前诊断方法还应包括所有在出生前对胎儿遗传学特征作出判断的方法,如产前亲子鉴定等。无创伤性产前诊断因具有无创伤性或创伤极小,孕妇易于接受,检查范围可扩展到非高危人群等潜在优势而成为近年最为活跃的研究领域之一。 作产前分子遗传学分析,首先要获取胎儿遗传信息的载体(遗传物质)。目前获取胎儿遗传物质的途径主要包括:(1)分离、富集孕妇外周血胎儿细胞; (2)收集宫腔脱落细胞;(3)直接利用孕妇血浆或血清中胎儿DNA。若能成功利用这
Non-invasive prenatal diagnosis, mainly refers to non-invasive means of fetus with any genetic disease or birth defects before birth to make accurate judgments. Broadly speaking, the prenatal diagnosis should include all methods of judging the genetic characteristics of the fetus before birth, such as prenatal paternity testing. Noninvasive prenatal diagnosis has become one of the most active research areas in recent years due to its potential advantages of being noninvasive or minimally invasive, being easily accepted by pregnant women, and scalable to non-at-risk populations. Prenatal molecular genetic analysis, we must first get the fetus genetic information carrier (genetic material). The current access to fetal genetic material mainly include: (1) separation and enrichment of fetal blood in pregnant women; (2) collection of uterine shedding cells; (3) direct use of maternal plasma or serum fetal DNA. If you can successfully use this