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为继续寻找能代替氯喹的天然抗疟药,对苦木科植物鸦胆子(Brucea javanica)果实进行了研究。鸦胆子在亚洲广泛分布,传统医学中用于治疗癌症、阿米巴痢疾和疟疾等多种疾病。和苦木科其它植物一样,鸦胆子的苦味成分也是苦木苦味素类(quas-sinoids),其中有些已进行过抗癌作用研究,最有效的成分之一埃鸦胆子苦素(bru-ceantin)正在美国进行临床试验。体外试验埃鸦胆子苦素还有较高的抗痢疾阿米巴(Entamoeba histolytica)活性。
In order to continue to find natural antimalarial drugs that can replace chloroquine, the fruit of Brucea javanica was studied. Brucea javanica is widely distributed in Asia and is used in traditional medicine for the treatment of various diseases such as cancer, amoebic dysentery and malaria. Like other plants of the Bitterwood family, the bitter components of Brucea javanica are also quas-sinoids, some of which have been studied for anti-cancer effects. One of the most effective components is bru-ceantin. ) is conducting clinical trials in the United States. In vitro tests of esculin have a higher anti-diarrhea amoeba (Entamoeba histolytica) activity.