论文部分内容阅读
目的探讨手足口病(HFMD)患儿血S100蛋白的变化及其临床意义。方法 40例HFMD患儿作为研究组。男22例,女18例;年龄9～64个月。另选择同期体检的30例健康儿童为健康对照组。男18例,女12例;年龄6个月～5岁。研究组按有无严重并发症分为非重症组(n=26)和重症组(n=14)。研究组于入院第2天,健康对照组于体检时采集空腹静脉血2～3 mL,分离血浆,采用ELISA法测定各组儿童血浆中S100蛋白水平。结果研究组S100蛋白水平[(0.77±1.17)ng.L-1]明显高于健康对照组[(0.34±0.19)ng.L-1](t=2.117,P<0.05),重症组[(0.93±1.42)ng.L-1]高于健康对照组(t=2.451,P<0.05),重症组与非重症组[(0.67±1.04)ng.L-1]、非重症组与健康对照组比较差异均无统计学意义(t=0.598、1.877,Pa>0.05)。结论 HFMD重症组患儿血S100蛋白显著增高,血S100蛋白可作为判定HFMD患儿严重程度的指标之一。
Objective To investigate the changes of serum S100 protein in children with hand-foot-mouth disease (HFMD) and its clinical significance. Methods Forty HFMD children were included in the study. 22 males and 18 females; aged 9 to 64 months. Another 30 healthy children who chose the same period of physical examination were healthy control group. 18 males and 12 females; aged 6 months to 5 years old. The study group was divided into non-severe group (n = 26) and severe group (n = 14) according to the presence or absence of serious complications. On the second day after admission, the healthy control group collected 2-3 mL of fasting venous blood at the time of physical examination, and the plasma was separated. The level of S100 protein in plasma of each group was measured by ELISA. Results The level of S100 in study group [(0.77 ± 1.17) ng.L-1] was significantly higher than that in healthy control group [(0.34 ± 0.19) ng.L -1] (t = 2.117, P 0.05) 0.93 ± 1.42) ng.L-1] was higher than that of the healthy control group (t = 2.451, P <0.05), but no significant difference between the severe and non-severe group (0.67 ± 1.04 ng · L -1) There was no significant difference between the two groups (t = 0.598,1.877, Pa> 0.05). Conclusion Serum S100 protein is significantly higher in children with severe HFMD and serum S100 protein may be used as one of the indicators to determine the severity of HFMD in children.