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目的:研究昼夜不同时间给予逍遥散对CCl4诱发大鼠肝损伤保护作用的差异。方法:采用sc40%CCl4制备大鼠肝损伤模型,分别于早上8点和晚上8点ig逍遥散,连续12d,观测大鼠一般行为状态、体重、血清丙氨酸氨基转换酶(ALT)和天门冬氨酸氨基转换酶(AST)、肝组织超氧化物岐化酶(SOD)和丙二醛(MDA)以及肝组织病理学变化。结果:与模型组比较,逍遥散能显著改善CCl4诱导大鼠肝损伤模型的体重曲线和行为状态;显著降低血清中ALT,AST含量;升高肝组织SOD的活性,降低MDA的含量;减轻肝脏病理损伤程度。同时,多数指标显示晚间给药和低剂量组的效果更好。结论:逍遥散具有明显的保肝降酶作用,其疗效与给药时间密切相关。
Objective: To study the protective effect of Xiaoyaosan on CCl4-induced liver injury in rats at different times of day and night. Methods: The rat model of hepatic injury was established by sc40% CCl4. The rats were randomly divided into 8 groups at 8 o’clock and 8 o’clock PM at night for 12 consecutive days. The general behavior, body weight, serum ALT, Aspartate aminotransferase (AST), liver tissue superoxide dismutase (SOD) and malondialdehyde (MDA) as well as liver histopathological changes. Results: Compared with the model group, Xiaoyao powder can significantly improve the body weight curve and behavioral status of CCl4-induced liver injury in rats; significantly reduce the serum ALT, AST levels; increase the activity of liver SOD, reduce the content of MDA; reduce the liver The degree of pathological damage. At the same time, most of the indicators show that evening and low dose groups work better. Conclusion: Xiaoyao San has obvious hepatoprotective effect, and its efficacy and administration time are closely related.