For the characteristics of the continuous stirred-tank reactor (CSTR) with coil and jacket cooling system, a CSTR temperature dual control solution based on the analysis of the CSTR exothermic reaction control characteristic was proposed for an organic material polymerization production. The control solution has passive fault-tolerant ability for the jacket cooling water cutting off fault and active fault-tolerant potential for the coil cooling water cutting off fault, and it has good control ability, high saving energy and reducing consumption performance. Fault detection and diagnosis and fault-tolerant control strategy are designed for the coil cooling fault to achieve the active fault-tolerant control function. The CSTR temperature dual control, process fault detection and diagnosis and active fault-tolerant control were full integrated into the CSTR temperature fault-tolerant control system, which achieve fault tolerance control of CSTR temperature for any severe malfunction of jacket cooling or coil cooling cutting off, and the security for CSTR exothermic reaction is improved. Finally, the effectiveness of this system was validated by semi-physical simulation experiment.