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目的验证胃癌的亚硝胺病因假说。方法在江苏省扬中县，对经过胃镜和病理确认的胃癌１０２例、萎缩性胃炎９０例、正常及浅表性胃炎１４６例，用气相色谱热能分析仪的方法，测定比较其胃液挥发性亚硝胺的含量，并用试纸法测定了胃液的ｐＨ值。结果胃液的ｐＨ值随胃粘膜的病变严重程度而上升。人群亚硝胺的总检出率在各组都很高，胃癌组、萎缩性胃炎组、正常及浅表性胃炎组的亚硝胺的总检出率分别为９９０２％、９８８９％、９８６３％。组间无显著差异（Ｐ＞００５）。但各种亚硝胺，如二甲基亚硝胺、二乙基亚硝胺、甲基卞基亚硝安、亚硝基吡咯烷、亚硝基哌啶的检出率，胃癌组、萎缩性胃炎组都比正常浅表性胃炎组有增高趋势。这种升高趋势从亚硝胺含量的比较上则更为显著。胃癌组和萎缩性胃炎组二甲基亚硝胺、二乙基亚硝胺含量及亚硝胺总量都比正常和浅表性胃炎组有显著增高（Ｐ＜００１）。结论亚硝胺可能与胃癌和萎缩性胃炎的发生有一定的关系。
Objective To verify the nitrosamine etiology hypothesis of gastric cancer. Methods A total of 102 cases of gastric cancer, 90 cases of atrophic gastritis, and 146 cases of normal and superficial gastritis were confirmed by gastroscopy and pathology in Yangzhong County, Jiangsu Province. Gas chromatography-thermal analysis method was used to determine and compare the volatile components of gastric juice. The content of nitramine was measured and the pH of the gastric juice was measured by a test paper method. Results The pH of gastric juice increased with the severity of gastric mucosal lesions. The total detection rate of nitrosamines in the population was high in all groups. The total detection rates of nitrosamines in the gastric cancer group, atrophic gastritis group, and normal and superficial gastritis groups were 99 02% and 98 89, respectively. %, 9863%. There was no significant difference between the groups (P>005). However, the detection rates of various nitrosamines, such as dimethylnitrosamine, diethylnitrosamine, methyl-nonylnitramine, nitrosopyrrolidine, and nitrosopiperidine, gastric cancer group, atrophy The gastritis group had an increased tendency than the normal superficial gastritis group. This increase trend is more significant from the comparison of nitrosamine content. The concentrations of dimethylnitrosamine, diethylnitrosamine, and total nitrosamines in the gastric cancer group and atrophic gastritis group were significantly higher than those in the normal and superficial gastritis groups (P < 0.01). Conclusion Nitrosamine may be related to the occurrence of gastric cancer and atrophic gastritis.