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目的:优选斑蝥的超微粉碎工艺。方法:以斑蝥素含量和粉体粒径D_(90)的总评归一值(OD)为评价指标,将入磨时含水量、粉碎时间、介质填充率作为考察因素,通过Box-Behnken效应面法优选斑蝥超微粉碎工艺,并考察斑蝥超微粉碎前、后斑蝥素的含量。结果:优选出斑蝥的最佳超微粉碎工艺为:入磨时含水量为6.0%,粉碎时间为17 min,介质填充率为70%;斑蝥超微粉碎前、后斑蝥素的含量分别约为0.3905%、0.4885%。结论:通过Box-Behnken效应面法和总评“归一值”优选出的斑蝥超微粉碎工艺合理可行、预测性良好,可为斑蝥的粉碎工艺提供参考。
Objective: To optimize cantharidin ultrafine grinding process. Method: The water content, crushing time and media filling rate were taken as the evaluation factors by taking the total value (OD) of the cantharidin content and the particle size D 90 as the evaluation index. Through the Box-Behnken effect surface Law cantharidin ultrafine grinding process, and examine cantharidin ultrafine grinding before and after the cantharidin content. Results: The best ultra-fine grinding technology was as follows: water content 6.0%, grinding time 17 min, medium filling rate 70%; the content of cantharidin before and after macular crushing were about 0.3905%, 0.4885%. CONCLUSION: It is reasonable and feasible to use the Box-Behnken effect surface method and the “normalized value” to optimize the cantharidin superfine pulverization process. The results show good predictability and provide a reference for the pulverization of cantharidin.