1型糖尿病是一胰岛 β细胞进行性破坏的自身免疫性疾病。β细胞破坏有两种方式 ,即坏死和凋亡。研究表明胰岛β细胞凋亡是 1型糖尿病 β细胞减少和缺失的主要原因[1] 。然而 ,是胰岛 β细胞自身免疫过程导致了 β细胞凋亡 ,还是 β细胞凋亡触发了 β细胞自身免疫反应 ,以及所涉 Type 1 diabetes is an autoimmune disease that is a progressive destruction of pancreatic beta cells. There are two ways that β-cell destruction occurs, namely necrosis and apoptosis. Studies have shown that pancreatic β-cell apoptosis is a major cause of type 1 diabetes β-cell loss and loss [1]. However, whether islet beta cell autoimmunity leads to beta-cell apoptosis or beta-cell apoptosis triggers the beta-cell autoimmune response and the implications