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目的:评价低剂量长疗程氟尿嘧啶(5-FU)静脉泵持续滴注治疗老年晚期胃癌的客观疗效及毒副反应。方法:117例老年晚期胃癌,采用低剂量5-FU375mg/d静脉泵持续24小时滴注,连用21天,联用低剂量亚叶酸钙(CF)25mg/m2、羟基喜树碱(HCPT)10mg和/或顺铂(PDD)10mg,每周各连用5天,共用3周。4周为1个周期,化疗2个周期。结果:117例患者均可评价疗效,获得CR9例(7.7%),PR58例(49.6%),RR67例(57.3%)。毒副反应主要为口腔炎(63.2%)、口腔溃疡(38.5%)、恶心呕吐(36.8%)、腹泻(30.8%)、粒细胞下降(25.6%)、便秘(17.9%)和静脉炎(6.0%),主要为Ⅰ~Ⅱ级毒副反应,对症处理后均能缓解。结论:低剂量长疗程5-FU持续滴注治疗老年晚期胃癌患者疗效好,毒副反应不严重,一般均能耐受,值得进一步研究。
Objective: To evaluate the objective curative effect and toxicity of continuous infusion of 5-fluorouracil (5-FU) intravenous infusion in elderly patients with advanced gastric cancer. Methods: A total of 117 elderly patients with advanced gastric cancer were treated with a low dose of 5-FU 375 mg / d intravenously for 24 hours. Combined with low-dose calcium folinate 25 mg / m2, HCPT 10 mg And / or cisplatin (PDD) 10mg, each for 5 days each for 3 weeks. 4 weeks for a cycle, chemotherapy 2 cycles. Results: All of the 117 patients were evaluated for efficacy. Among them, CR9 (7.7%), PR58 (49.6%), RR 67 (57.3%) were obtained. The main side effects were stomatitis (63.2%), oral ulcer (38.5%), nausea and vomiting (36.8%), diarrhea (30.8%), neutrophil drop (25.6%), constipation (17.9%) and phlebitis %), Mainly for grade Ⅰ ~ Ⅱ toxic side effects, can alleviate symptomatic treatment. CONCLUSION: Low-dose, long-course 5-FU continuous infusion is effective in treating elderly patients with advanced gastric cancer, and its toxicity and side effects are not serious and generally worthy of further study.