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目的探讨低、高频闭环电刺激对氯化铁癫痫模型大鼠的治疗效果。方法给予SD大鼠头颅额、顶、枕部铺设硬膜外电极6枚,用立体定向方法在大鼠感觉运动皮质区注入氯化铁溶液,建立癫痫模型,分别给予低频刺激(1Hz)和高频刺激(100Hz),同时给予8小时脑电监测。分析大鼠8小时内发作总次数和发作总时间。结果低频和高频电刺激均能抑制大鼠的癫痫发作,而高频与低频刺激在治疗效果上无明显统计学差异。结论低频刺激为较佳的刺激方式。
Objective To investigate the therapeutic effect of low and high frequency closed-loop electrical stimulation on rats induced by iron chloride epilepsy. Methods Eighteen epidural electrodes were applied to the frontal, parietal and occipital sections of SD rats. Iron chloride solution was injected into the sensory cortex of rats by stereotactic method. The epilepsy model was set up and the rats were given low frequency stimulation (1 Hz) and high Frequency stimulation (100Hz), while giving 8 hours EEG monitoring. The total number of attacks and total attack time within 8 hours were analyzed. Results Both low-frequency and high-frequency electrical stimulation could inhibit the seizure in rats. There was no significant difference in the therapeutic effect between high-frequency and low-frequency stimulation. Conclusion Low-frequency stimulation is the best way to stimulate.