60年代初 Frekel 等首次报告由营养变异链球菌(NVS)引起的亚急性细菌性心内膜炎。这种心内膜炎占链球菌心内膜炎总病例数的5～10%。本病有较高的治疗失败、复发和死亡率,日益受到人们的注意。加之 NVS 在常规培养基上不易生长,常导致误、漏诊,为了提高其诊断水平,本文就有关临床特点,实验诊断方法的新进展作一简介。 In the early 1960s Frekel et al. First reported subacute bacterial endocarditis caused by Streptococcus mutans (NVS). This type of endocarditis accounted for 5 to 10% of the total number of cases of streptococcal endocarditis. The disease has a higher treatment failure, recurrence and mortality, more and more people’s attention. In addition, NVS is not easy to grow on conventional medium and often leads to errors and missed diagnosis. In order to improve its diagnostic level, this article gives a brief introduction about the clinical features and new progress of experimental diagnosis.