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目的探讨中国汉族人T2DM患者ACE基因缺失型(DD型)基因多态性和DN的关系。方法采用Meta分析系统评价ACE DD基因型与DN的相关关系。使用Cochrane协作组提供的Revman5.0.23软件合并DD基因型频率统计量Peto OR值及其95%CI。结果共纳入29个符合条件的病例对照研究,DN组2295例,非DN对照组2197例。结果示Peto OR值1.93[95%CI(1.68,2.23)],合并统计值Z=9.06,P<0.01。敏感性分析提示该Meta分析结果较为可靠。漏斗图呈对称性分布,提示无明显的发表偏倚。结论中国汉族人DN与ACE插入/缺失多态性显著相关,ACE DD基因型是DN的危险因子。
Objective To investigate the relationship between ACE gene deletion polymorphism (DN) and DN in Chinese Han population with T2DM. Methods Meta analysis was used to evaluate the association between ACE DD genotypes and DN. Using the Revman 5.0.23 software provided by the Cochrane Collaboration, the Peto OR values for DD genotype statistics and 95% CI were combined. Results A total of 29 eligible case-control studies were included, 2295 cases in DN group and 2197 cases in non-DN control group. The results showed a Peto OR of 1.93 [95% CI (1.68,2.23)] with a pooled statistic of Z = 9.06, P <0.01. Sensitivity analysis suggests that the Meta analysis is more reliable. The funnel plot showed a symmetry distribution, suggesting no obvious publication bias. Conclusions There is a significant association between DN and ACE insertion / deletion polymorphisms in Chinese Han population, ACE DD genotype is a risk factor for DN.