本文报道新型手性杯[4]氮杂冠醚衍生物的简便合成.即在路易斯酸(ZnCl2)催化下,二氰基取代杯[4]芳烃与各种光学活性的1,2-氨基醇反应,高产率得到了手性杯[4]氮杂冠醚衍生物.该方法具有反应条件温和、操作简便、产率高等特点.产物的晶体X-衍射及ESI-MS数据表明,通过主客体之间的O–H…π作用,杯芳烃上沿的空腔对甲醇分子具有较强的包结作用. In this paper, a simple synthesis of novel aza-crown-ether derivatives of chiral calix [4] aza crown ethers is reported, which is the reaction of dicyano-substituted calix [4] arene with various optically active 1,2-amino alcohols Reaction and high yield of azacrown calix [4] aza crown ethers. The method has the advantages of mild reaction conditions, simple operation, high yield and the like. The crystal X-ray diffraction and ESI-MS data of the product show that the chiral calix [4] Between the role of O-H ... π, calixarene cavities along the methanol molecules have a stronger inclusion role.