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目的观察中西医结合治疗方案对慢性心力衰竭的疗效及其生活质量的影响。方法采用随机双盲安慰剂对照试验设计方法 ,选择150例慢性心力衰竭患者(剔除2例、脱落3例)分为试验组71例和对照组73例,分别采用中西医结合疗法和西药加中药安慰剂疗法治疗,并使用明尼苏达生活质量问卷(Minnesota Living with Heart Failure Questionnaire,mlHFQ),评价患者的生活质量水平,使用心衰评分表评价患者的心衰改善水平。结果两组在治疗8周、12周心衰评分比较差异均无统计学意义(P﹥0.05);与对照组比较,试验组患者治疗24周后心衰程度明显改善(P﹤0.05);两组4周mlHFQ评分比较差异均无统计学意义(P﹥0.05),治疗8周～24周后,试验组mlHFQ评分较对照组低,差异有统计学意义(P﹤0.01)。可以看出中医综合治疗方案有改善慢性心力衰竭患者生活质量的趋势,并且随着随访日期的延长,差异越显著。结论中西医结合治疗方案可降低慢性心力衰竭再次住院率,有改善患者24周生活质量的趋势。
Objective To observe the effect of integrated traditional Chinese and western medicine on curative effect and quality of life of patients with chronic heart failure. Methods A randomized, double-blind, placebo-controlled trial was designed. One hundred and fifty patients with chronic heart failure (excluding 2 and 3 exfoliated) were divided into experimental group (71 cases) and control group (73 cases) Placebo therapy and the use of the Minnesota Living with Heart Failure Questionnaire (mlHFQ) to assess the patient’s quality of life and to assess the improvement in heart failure using the heart failure scale. Results There was no significant difference in the scores of heart failure between the two groups at 8 weeks and 12 weeks (P> 0.05). Compared with the control group, the heart failure rate of the experimental group was significantly improved after 24 weeks treatment (P <0.05) There was no significant difference in the scores of mlHFQ between the two groups (P> 0.05). After 8 weeks to 24 weeks of treatment, the scores of mlHFQ in the experimental group were lower than those in the control group (P <0.01). It can be seen that the comprehensive treatment of traditional Chinese medicine to improve the quality of life in patients with chronic heart failure trend, and with the extension of follow-up, the more significant differences. Conclusion The combination of traditional Chinese and western medicine can reduce the re-hospitalization rate of chronic heart failure and improve the quality of life of patients at 24 weeks.