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目的:探讨结直肠癌肺转移患者手术切除肺转移灶的疗效及术后生存的影响因素。方法:回顾性分析79例结直肠癌肺转移灶切除患者的临床资料,统计分析其生存期及预后影响因素。结果:全组患者中位随访时间52.0个月。中位生存时间36.0个月,5年生存率为35.1%。29例患者死于肿瘤进展;27例生存患者中,18例带瘤生存,9例无瘤生存,其中1例至今已无瘤生存159个月。单因素分析结果显示,无瘤间期(DFI)时间的长短对肺转移瘤切除术后的生存有影响(P=0.036);而患者的性别、年龄、原发肿瘤部位、肺转移瘤大小和位置、手术方式、肺转移瘤手术前CEA水平及复发后再次行肺转移瘤切除均与其术后生存时间无关。结论:对于结直肠癌肺转移患者,手术是有潜在治愈可能的治疗方法。DFI可能与肺转移瘤切除术后生存有关。
Objective: To investigate the curative effect of operative resection of lung metastasis in patients with lung metastasis of colorectal cancer and the influencing factors of postoperative survival. Methods: The clinical data of 79 patients with resected lung metastases of colorectal cancer were retrospectively analyzed. The survival and prognostic factors were statistically analyzed. Results: The median follow-up time was 52.0 months in all patients. The median survival time was 36.0 months, and the 5-year survival rate was 35.1%. Twenty-nine patients died of tumor progression. Of the 27 patients who survived, 18 had tumor-free survival and 9 had no tumor-free survival, of which 1 had a tumor-free survival of 159 months. The results of univariate analysis showed that the duration of the no-tumor interval (DFI) had an effect on the survival after resection of lung metastases (P = 0.036), while the gender, age, primary tumor site, lung metastases size and Location, operation mode, CEA level before operation of lung metastasis and resection of lung metastasis after recurrence all had nothing to do with the postoperative survival time. Conclusions: Surgery is a potential cure for colorectal cancer patients with lung metastases. DFI may be related to survival after resection of lung metastases.