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目的:探讨缺氧诱导因子-1α(HIF-1α)在中晚期宫颈癌组织中的表达,了解放射抵抗性机制,为宫颈癌的临床个体化治疗,预后判断提供参考指标。方法:采用免疫组化二步法检测49例中晚期宫颈癌组织(其中20例为放疗后完全缓解组,29例为放疗后末控组)中的HIF-1α的阳性表达。结果:1.HlF-1α在宫颈癌放疗后未控组的阳性表达率为89.66%,放疗后完全缓解租的阳性表达率为65%,两组之间表达有差异性,差异性有统计学意义(χ2=8.036,P<0.05)。结论:HIF-1α可能在宫颈癌放射治疗过程中起主要的作用,可作为宫颈放射治疗疗效的预测指标及预测预后指标,同时HIF-1α也可能成为宫颈癌治疗的新参考指标。
Objective: To investigate the expression of hypoxia-inducible factor-1α (HIF-1α) in advanced cervical cancer and to understand the mechanism of radiation resistance and to provide a reference index for clinical individualized treatment and prognosis of cervical cancer. Methods: The positive expression of HIF-1α in 49 patients with advanced cervical cancer (20 of whom were in complete remission group and 29 in control group after radiotherapy) was detected by immunohistochemical two-step method. Results: 1. The positive expression rate of HLF-1α in uncontrolled cervical cancer patients after radiotherapy was 89.66%, and the positive expression rate of complete remission after radiotherapy was 65%. There was significant difference between the two groups Significance (χ2 = 8.036, P <0.05). Conclusion: HIF-1α may play a major role in the radiation therapy of cervical cancer. It may be used as a predictor of prognosis and prognosis of cervical radiation therapy. HIF-1α may also be a new reference index for the treatment of cervical cancer.