【摘 要】
：
We investigated whether letrozole (2.5 mg day-1) improves sperm count in non-obstructive azoospermia (NOA) patients.Four men were included in this study,and they had folliculo-stimulating hormone and other hormone levels within the normal range and no var
【机 构】
：
Andros-Italia, Outpatient Clinic of Ferrara, Via Mascheraio 46, Ferrara 44121, Italy;Centro Italiano
论文部分内容阅读
We investigated whether letrozole (2.5 mg day-1) improves sperm count in non-obstructive azoospermia (NOA) patients.Four men were included in this study,and they had folliculo-stimulating hormone and other hormone levels within the normal range and no varicoceles or chromosomal aberrations.These four patients were administered letrozole for 3 months.Sperm count,testicular volume,gonadotropin,testosterone (T) and estradiol (E2) blood levels were assessed before,during and 1 week after the suspension of treatment.All patients showed spermatozoa in their ejaculate,increased gonadotropin and T levels and lower E2 levels (P＜O.05 in all cases),when letrozole was administered.This suggests that letrozole treatment might improve sperm count in an NOA sub-population;however,more studies,including the proper controls,are needed to confirm its efficacy.
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