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目的:探讨芒果苷对大鼠局灶性脑缺血/再灌注损伤的影响及其作用机制。方法:将SD大鼠随机分为6组:假手术组、模型组、尼莫地平(5 mg.kg-1)组及芒果苷高、中、低剂量(20,10,5 mg.kg-1)组。采用线栓法建立大鼠局灶性脑缺血/再灌注模型。观察芒果苷对大鼠神经行为和脑梗死面积的影响。测定大鼠脑组织中丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性。结果:芒果苷可明显改善大鼠神经功能缺陷,减少脑梗死面积,降低脑组织MDA含量,提高脑组织超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)的活性。结论:芒果苷有抗脑缺血/再灌注损伤作用,作用机制可能与其抗氧化作用有关。
Objective: To investigate the effect of mangiferin on focal cerebral ischemia / reperfusion injury in rats and its mechanism. Methods: The SD rats were randomly divided into 6 groups: sham operation group, model group, nimodipine (5 mg.kg-1) group and high, medium and low dose of mangiferin (20, 10, Group 1. Focal cerebral ischemia / reperfusion model was established by thread occlusion. To observe the effect of mangiferin on neurobehavioral and cerebral infarction area in rats. The content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in rat brain were measured. Results: Mangiferin significantly improved neurological deficits, reduced infarct size, reduced MDA content in brain tissue, and increased the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in brain tissue active. Conclusion: Mangiferin has anti-cerebral ischemia / reperfusion injury and its mechanism may be related to its antioxidative effect.