不能手术的枝气管癌姑息性放疗的作用

来源 :国外医学(临床放射学分册) | 被引量 : 0次 | 上传用户:miracle_l
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作者对66例未曾放化疗、不能手术的枝气管癌作了姑息性放疗的前瞻性研究。最初病变的范围用临床检查、照片及枝气管镜确定,亦包括远处转移者。症状分为无、轻、中与重度四级,体力状态(RS)按WHO规定记分。用6MV直线加速器或60钻放疗。大多为平行对穿野,包括原发灶与局部蔓延区,剂量从18GY/5次(TDF41)~48GY分段:即24GY/5次,休息一个月,再给24GY/5次(TDF114);剂量计算到中点,未作不均等组织校正。胸外骨转移灶一般给25GY/5次。照射后六个月内按周评定疗效。作者见到,全组中数生存38周。在随诊3、6个月内大多数症状(咳嗽、呼吸困难与咯血)均控制良好。对PS无明显影响。吞咽困难仅有14%改善。胸外症状如疲乏、厌食与体重减轻的效应亦差,仅20%体重增加,45%稳 The authors performed a prospective study of palliative radiotherapy for 66 patients with non-radiotherapy and inoperable tracheal carcinoma. The extent of the initial lesion was determined by clinical examinations, photographs, and bronchoscopes, also including distant metastases. Symptoms were divided into four grades: none, mild, moderate, and severe. Physical status (RS) was scored according to WHO guidelines. Use 6MV linear accelerator or 60 drill radiation therapy. Most of them were parallel to the field, including the primary tumor and the local continuation area. The dose ranged from 18GY/5 times (TDF41) to 48GY: 24GY/5 times, one month rest, and 24GY/5 times (TDF114). The dose was calculated to the midpoint without correction for inhomogeneous tissue. Chest bone metastases generally give 25GY/5 times. The curative effect was evaluated on a weekly basis within six months after irradiation. The author saw that the entire group survived 38 weeks. Most of the symptoms (cough, dyspnea, and hemoptysis) were well controlled within 3 and 6 months of follow-up. No significant effect on PS. Only 14% of dysphagia improved. The effects of chest symptoms such as fatigue, anorexia, and weight loss were also poor, with only 20% of weight gain and 45% stable.
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