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对108例胃癌患者的家系及相匹配的对照组家系进行遗传流行病学研究。采用 Li-Mantel-Gart 法计算胃癌的分离比,结果为0.024。同时采用 Falconer 法估算胃癌的遗传度,结果为40.86%±12.32%。表明胃癌系多基因遗传病,遗传因素在胃癌的发生中起着重要作用。
A genetic epidemiological study was conducted on the families of 108 patients with gastric cancer and the matched control family. The separation ratio of gastric cancer was calculated using the Li-Mantel-Gart method and the result was 0.024. The Falconer method was used to estimate the heritability of gastric cancer. The result was 40.86% ± 12.32%. This indicates that gastric cancer is a multigenic genetic disease, and genetic factors play an important role in the development of gastric cancer.