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目的 :探讨一氧化氮 (NO)与肝癌及其合并症、肝硬化、肝功能分级及肝硬化并发症的关系。方法 :应用化学比色法检测34例肝癌患者 ,45例肝硬化患者及20例正常人血清NO水平。结果 :肝癌组血清NO显著高于肝硬化组及正常对照组 ;肝癌合并代偿期肝硬化血清NO高于合并慢性肝炎者 ;肝硬化组血清NO与正常对照组比较 ,差异有显著性 ;并且随肝功能Child -Pugh分级的增加而升高 ,A级与对照组比较无差异 ,B级与A级、B级与C级比较 ,差异有显著性。并发肝肾综合征、食管胃底静脉曲张破裂出血者较无并发症肝硬化者NO明显升高。结论 :内源性NO在肝癌及肝硬化时合成增加 ,且与肝癌合并症、肝硬化病情严重程度及并发症的发生密切相关。血清NO测量有助于肝癌及肝硬化病情的临床评估及疗效观察
Objective: To investigate the relationship between nitric oxide (NO) and liver cancer and its complications, cirrhosis, grade of liver function and complications of liver cirrhosis. Methods: The serum levels of NO in 34 patients with liver cancer, 45 patients with cirrhosis and 20 normal controls were detected by colorimetric assay. Results: The serum NO level in HCC group was significantly higher than that in cirrhosis group and normal control group. The serum NO level in HCC with compensated cirrhosis was higher than that in chronic liver disease group. The serum NO level in cirrhosis group was significantly higher than that in control group With Child-Pugh classification of liver function increased, A level and the control group no difference, B and A, B and C level, the difference was significant. Concurrent hepatorenal syndrome, esophageal variceal bleeding compared with no complications of liver cirrhosis were significantly higher NO. CONCLUSION: Endogenous nitric oxide (NO) synthesis increases in hepatocellular carcinoma and cirrhosis, and is closely related to the incidence of hepatocellular carcinoma, the severity of liver cirrhosis and complications. Serum NO measurement contributes to the clinical evaluation and curative effect of liver cancer and cirrhosis