鬼臼毒素对人K562白血病细胞的作用研究

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采用MTT法和流氏细胞仪技术,研究了天然药物鬼臼毒素(podophyllo的xin)对人慢性髓细胞性白血病K562细胞凋亡及细胞周期的影响.结果表明,鬼臼毒素对K562细胞的IC50是79.19 umol.L-1;以IC50药物浓度作用人K562细胞24h,细胞凋亡率达到31.96%,G0-G1期峰前有亚二倍体峰出现,此结果说明鬼臼毒素能快速有效地诱导K562细胞发生凋亡.
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