1960年Jennings等[1]第一次提出心肌缺血再灌注损伤的概念,证实再灌注会引起心肌超微结构不可逆坏死,并逐渐引起医学界的高度重视。缺血心肌恢复再灌注后,病情反而恶化,引起超微结构、功能、代谢及电生理方面发生进一步的损伤,是由于在缺血损伤的基础上再次引起的损伤,因此称为 In 1960 Jennings et al [1] first proposed the concept of myocardial ischemia-reperfusion injury, confirmed that reperfusion can cause irreversible necrosis of myocardial ultrastructure, and gradually attracted the medical community’s attention. Myocardial ischemia-reperfusion injury, the condition worsened, causing ultrastructural, functional, metabolic and electrophysiological further damage occurs because of the basis of the ischemic injury caused by the re-injury, it is called