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自1980年组织培养人用狂犬病疫苗在武汉鉴定投产以来,国内普遍生产和使用,反应轻微,效果良好,为了更有效地发挥免疫预防、控制狂犬病的作用,我们采用国际法(NIH)检测狂犬病疫苗效价,于1985年5月开始在湘潭地区对受疯动物咬伤的患者比较观察疫苗与抗血清加疫苗的兔疫效果,同时在两组对象中,也比较不同免疫程序对效果的影响。显示改进的免疫程序同样收到较好的预防效果,其早期抗体应答不比常规法低,且免疫持久性较好些。观察三年半均未发现无效病例。 材料与方法 一、疫苗 武汉所出品,批号85226,效价3IU/AmP。抗血清批号8502,效价121IU/ml~*。 二、对象与分组 于狂犬病疫区第一次受疯动物咬伤,无狂术病疫苗与抗血清使用史,年龄6～76岁。按受伤时间先后、伤势轻重分组。凡严重咬伤者
Since 1980, when human rabies vaccines were organized and put into production in Wuhan, it has been widely produced and used domestically with slight reaction and good effect. In order to exert immunoprophylaxis and control the rabies more effectively, we use NIH to test rabies vaccine effectiveness Price, in May 1985 began to Xiangtan area of bites in rabbits compared to the vaccine and the antiserum plus vaccine vaccine effect, while in both groups, but also compare the impact of different immunization programs on the effect. This shows that the improved immunization program also received better prophylaxis with less early antibody response than conventional methods and better immune persistence. Three and a half years did not find any invalid cases. Materials and methods First, the vaccine produced in Wuhan, batch number 85226, titer 3IU / AmP. Antiserum lot 8502, titer 121IU / ml ~ *. Second, the object and the group Rabies disease area for the first time by the bite of mad animals, no wild-type vaccine and antiserum history, aged 6 to 76 years. Accident time by accident, the severity of grouping. Who severely bitten