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骨髓移植是治疗造血系统恶性肿瘤、再生障碍性贫血等的重要手段之一,但移植后的移植物抗宿主病(GVHD)在很大程度上限制了其临床应用。GVHD发生中T细胞活化起到了重要的作用,因此阻断协同剌激途径抑制T细胞活化成为预防GVHD的策略之一;临床和科学实验的结果均显示抑制GVHD的措施
Bone marrow transplantation is an important means of treating hematopoietic malignancies and aplastic anemia. However, graft-versus-host disease (GVHD) after transplantation greatly limits its clinical application. T cell activation plays an important role in the pathogenesis of GVHD, so blocking the co-stimulatory pathway to inhibit T cell activation becomes one of the strategies to prevent GVHD. The results of clinical and scientific experiments have shown that inhibition of GVHD