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目的探讨癫癎无发作2年以上的患者抗癫癎药(AEDs)撤药前脑电图异常(样放电)的可能影响因素。方法根据入组标准共筛选229例癫癎控制、达到无发作2年以上患者,收集相关临床资料并进行统计学分析。结果在229例患者中,脑电图持续异常者为48例(21.0%)。多因素分析发现首次发作后脑电图出现异常放电(P=0.000,OR=9.07,95%CI:3.39-24.28)以及多药联合治疗(P=0.019,OR=2.70,95%CI:1.17-6.17)是脑电图持续异常(样放电)的相关危险因素。结论癫癎首次发作后脑电图异常(样放电)、AEDs多药联合治疗是癫癎发作控制患者的脑电图持续异常(样放电)的危险因素,撤药应慎重。
Objective To investigate the possible influencing factors of anomalies of electroencephalogram (like discharge) before withdrawal of antiepileptic drugs (AEDs) in patients with epileptic seizures more than 2 years. Methods Based on the inclusion criteria, a total of 229 cases of epilepsy control were screened to reach patients who did not have seizures for more than 2 years. Relevant clinical data were collected and statistically analyzed. Results In 229 patients, 48 cases (21.0%) had abnormal EEG. Multivariate analysis showed abnormal EEG discharges after the first episode (P = 0.000, OR = 9.07, 95% CI: 3.39-24.28) and multidrug combination therapy (P = 0.019, OR = 2.70, 95% CI: 1.17-6.17 ) Is a relevant risk factor for persistent anomalies (like discharges) of the EEG. Conclusion After the first episode of epilepsy, the EEG is abnormal (like discharge). AEDs multi-drug combination therapy is a risk factor for the continuous abnormality of EEG (sample discharge) in patients with epileptic seizures.