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Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain.However,compared with the expression and function of bioactive mature domain,the biological role of the pro-domain is poorly understood.Unexpectedly,we found that the pro-domain(or pro-peptide)of brain-derived neurotrophic factor(BDNF),which is well-known neurotrophic factor in brain,has a potential ability to facilitate hippocampal long-term depression.Furthermore,a BDNF polymorphism Val66Met,which substitute valine into methionine at 66 amino acid,impacted the biological activity of the BDNF pro-peptide.We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.
Most growth factors are preposed as precursors and it was cleaved into bioactive mature domain and pro-domain. However, compared with the expression and function of bioactive mature domain, the biological role of the pro-domain is poorly understood. Unexpectedly, we found that the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which is well-known neurotrophic factor in brain, has a potential ability to facilitate hippocampal long-term depression. which substitute valine into methionine at 66 amino acid, impacted the biological activity of the BDNF pro-peptide. We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.