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目的:对比观察血浆置换与血液灌流治疗重症稀料中毒的临床疗效。方法:选择重症稀料中毒102例,随机分为观察组52例和对照组50例,在常规治疗基础上,对照组采用血液灌流治疗,观察组采用新鲜冰冻血浆进行血浆置换治疗。观察对比两组治疗后神志开始恢复及完全恢复时间、生化指标变化、住院时间及治疗总有效率。结果:观察组神志开始恢复时间、神志完全恢复时间及住院时间均显著短于对照组(P<0.05);观察组谷丙转氨酶(ALT)、碱性磷酸酶(ALP)、谷草转氨酶(AST)、总胆红素(STB)、直接胆红素(CB)水平均显著优于对照组(P<0.05),两组尿素氮(BUN)和间接胆红素(UCB)水平均差异不显著(P>0.05);观察组治疗总有效率94.2%,显著高于对照组的72.0%(P<0.05)。结论:血浆置换治疗重症稀料中毒,临床效果和救治成功率优于血液灌流。
Objective: To compare the clinical effects of plasma exchange and hemoperfusion in the treatment of severe nephrotoxicity. Methods: 102 cases of severe nephrotoxicosis were randomly divided into observation group (n = 52) and control group (n = 50). On the basis of routine treatment, the control group was treated with hemoperfusion and the observation group was treated with fresh frozen plasma for plasmapheresis. Observe and compare two groups after treatment, consciousness began to recover and complete recovery time, biochemical changes, hospitalization time and the total effective rate. Results: The recovery time, consciousness complete recovery time and hospitalization time in the observation group were significantly shorter than those in the control group (P <0.05). The levels of ALT, ALP, AST, , Total bilirubin (STB) and direct bilirubin (CB) were significantly higher than those of the control group (P <0.05). The levels of BUN and UCB were not significantly different between the two groups P> 0.05). The total effective rate of the observation group was 94.2%, which was significantly higher than that of the control group (72.0%, P <0.05). Conclusion: Plasma exchange is more effective than hemoperfusion in treating severe noxious poisoning.