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氯哌胺(Loperamide)是一种新型止泻药,能拮抗15-M-PGF_(2α)引起的小鼠小肠内碳粉推进加速和腹泻,作用比吗啡和阿托品强,对离体大鼠回肠的抑制作用也比吗啡、阿托品强。氯哌胺能降低肠平滑肌张力,抑制离体大鼠回肠对15-M-PGF_(2α)的反应性,但却增强子宫平滑肌对15-M-PGF_(2α)的反应性。氯哌胺对离体大鼠子宫自发收缩活动低浓度兴奋、高浓度抑制。氯哌胺对15-M-PGF_(2α)促进大鼠空肠水和钠离子分泌也有拮抗作用,此作用不能被纳洛酮翻转。氯哌胺在小鼠的急性半数致死量为77.9 mg/kg。
Loperamide is a new antidiarrheal agent that can antagonize 15-M-PGF_ (2α) -induced accelerated intestinal transit of small intestine and diarrhea in mice, and its effect is stronger than that of morphine and atropine. Inhibition is also stronger than morphine, atropine. Clopidam could reduce the intestinal smooth muscle tension and inhibit the reactivity of isolated rat ileum to 15-M-PGF_ (2α), but enhance the reactivity of uterine smooth muscle to 15-M-PGF_ (2α). Clopidogrel on spontaneous contraction of isolated rat uterine activity of low concentrations of excitement, high concentrations of inhibition. Clomipramine also antagonized the secretion of sodium and water by sodium 15-M-PGF_ (2α) in jejunum, which can not be reversed by naloxone. The acute median lethal dose of clopidan in mice was 77.9 mg / kg.