哌氟沙星[pefloxacin,1-乙基-6-氟-1,4-二氢-7-(4-甲基-1-哌嗪基)-4-氧-3-喹啉羧酸]是一种抗革兰氏阳性和革兰氏阴性菌的广谱抗菌药物。药动学实验证明,大部分药物在代谢后从尿中排除,半衰期为11h。原形药尿中排泄8～9％。目前已有的临床结果说明,该药适于抗严重的合并细菌感染,尤其是抗肾脏和泌尿道感染。因而,研究肾功能损伤病人的药动学具有重要 Pefloxacin [1-Ethyl-6-fluoro-1,4-dihydro-7- (4-methyl-1-piperazinyl) -4-oxo-3-quinolinecarboxylic acid] is A broad spectrum antimicrobial drug resistant to Gram-positive and Gram-negative bacteria. Pharmacokinetic experiments show that most of the drugs are excluded from the urine after metabolism, half-life of 11h. Prototype urinary excretion of 8 to 9%. The current clinical results show that the drug is suitable for combating severe combined bacterial infection, especially anti-kidney and urinary tract infections. Therefore, it is important to study the pharmacokinetics of patients with impaired renal function