某些工业化学物可渗透皮肤进入血循环,在一个或多个靶器官引起全身毒性,或诱发全身过敏反应。本文主要根据实验和临床资料概述因皮肤吸收化学物引起的全身毒性。为提出职业接触工业化学物的预防措施提供依据。工业化学物的经皮吸收皮肤对化学物的主要屏障在角质层,化学物以被动扩散方式通过皮肤屏障,而不是主动转运。在表皮角质细胞的间质中充满非极性的脂类物质,可能是某些化学物渗透皮肤的主要途径。化学物一旦渗透角质层,就很易进入全身循环。不同个体或同一个体的不同解剖部 Certain industrial chemicals penetrate the skin and enter the bloodstream, causing systemic toxicity in one or more target organs or inducing a systemic allergic reaction. This article summarizes the systemic toxicity due to skin absorption chemicals based primarily on experimental and clinical data. Provide a basis for proposing preventive measures against occupational exposure to industrial chemicals. Percutaneous absorption of industrial chemicals The main barrier to chemicals in the skin is in the stratum corneum, chemicals pass through the skin barrier in a passive diffusion rather than active transport. Filling the interstitium of epidermal keratinocytes with non-polar lipids may be the main route for certain chemicals to penetrate the skin. Once the chemical penetrates the stratum corneum, it is easy to enter the systemic circulation. Different individuals or different anatomy of the same individual