论文部分内容阅读
人巨细胞病毒(HCMV)是目前已知最大的β疱疹病毒。HCMV感染具有持续性和潜在性,感染率在全世界范围内都很高,并随着年龄的增长而升高,女性感染率高于男性,其主要的传播途径有垂直传播和性传播等。近年来的研究显示在人类胶质瘤、结直肠癌、乳腺癌和前列腺癌及小细胞型肝癌等多种类型的肿瘤组织中都存在HCMV感染和病毒基因表达,并与肿瘤的恶性程度有相关性,这提示HCMV可能在人类某些类型肿瘤的形成和发展过程中扮演重要角色,有可能成为一种新的人类肿瘤相关病毒。HCMV基因产物可通过多种细胞信号通路抑制细胞凋亡、促进细胞增殖、侵袭、转移和血管生成,并形成独特的免疫逃避机制对抗机体免疫反应。深入研究HCMV与肿瘤的病因学关系及其作用机制,可为肿瘤的临床防治提供新思路。
Human cytomegalovirus (HCMV) is the largest beta herpes virus currently known. HCMV infection is persistent and potentially infectious. The prevalence of HCMV infection worldwide is high and increases with age. The prevalence of HCMV infection is higher in males than in males. The main transmission routes of HCMV infection are vertical transmission and sexual transmission. In recent years, studies have shown HCMV infection and viral gene expression in many types of human glioma, colorectal cancer, breast cancer and prostate cancer and small cell hepatocellular carcinoma, and is associated with the degree of malignancy of the tumor This suggests that HCMV may play an important role in the formation and development of certain types of human tumors and may become a new human tumor-associated virus. HCMV gene products can inhibit cell apoptosis through a variety of cell signaling pathways, promote cell proliferation, invasion, metastasis and angiogenesis, and form a unique immune evasion mechanism against the body’s immune response. In-depth study of the etiology of HCMV and tumor mechanism and its mechanism of action for the clinical prevention and treatment of cancer provide new ideas.