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目的研究子宫内膜异位症相关性卵巢癌的临床病理特点,为临床诊断和治疗预后判断提供参考依据。方法 218例卵巢癌患者,按照患者是否并发子宫内膜异位症将其分为卵巢癌合并子宫内膜异位症的研究组35例,和单纯性卵巢癌的对照组183例。回顾性分析两组患者年龄、病理类型、细胞分化以及临床病理分期。结果研究组患者比对照组患者平均年龄小4岁(P<0.05)。研究组卵巢子宫内膜样癌和透明细胞癌比例显著高于对照组(P<0.05);对照组浆液性癌比例显著高于研究组(P<0.05);研究组和对照组黏液性癌和其他类型比例差异无统计学意义(P>0.05)。研究组组织分化程度以高度和中度分化为主,对照组组织分化程度以中度和低度分化为主。研究组临床Ⅱ期显著高于对照组(P<0.05);对照组临床Ⅲ期显著高于研究组(P<0.05);研究组临床Ⅰ期和临床Ⅳ期与对照组比较差异无统计学意义(P>0.05)。结论子宫内膜异位症相关性卵巢癌患者比单纯性卵巢癌患者平均年龄小,恶性细胞分化程度高,临床分期靠前,病理类型主要是卵巢子宫内膜样癌和透明细胞癌。
Objective To study the clinicopathological features of ovarian cancer associated with endometriosis and provide reference for clinical diagnosis and treatment prognosis. Methods A total of 218 patients with ovarian cancer were divided into study group (35 cases) with ovarian cancer complicated with endometriosis and control group (183 cases) with simple ovarian cancer according to whether the patients had complicated endometriosis. Retrospective analysis of two groups of patients age, pathological type, cell differentiation and clinical pathological stage. Results The study group had a mean age of 4 years younger than the control group (P <0.05). The proportion of ovarian endometrioid carcinoma and clear cell carcinoma in the study group was significantly higher than that in the control group (P <0.05); the proportion of serous carcinoma in the control group was significantly higher than that in the study group (P <0.05); in the study group and the control group, There was no significant difference in other types (P> 0.05). The degree of differentiation in the study group was highly and moderately differentiated, while that in the control group was moderately and poorly differentiated. The clinical stage Ⅱ in the study group was significantly higher than that in the control group (P <0.05); the clinical stage Ⅲ in the control group was significantly higher than that in the study group (P0.05); there was no significant difference between the clinical stage Ⅰ and Ⅳ in the study group and the control group (P> 0.05). Conclusions Patients with endometriosis-related ovarian cancer have a lower mean age, higher degree of malignant cell differentiation and more advanced clinical stages than those with simple ovarian cancer. The pathological types are mainly ovarian endometrial carcinoma and clear cell carcinoma.