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目的：探讨有创-无创机械通气序贯治疗慢性阻塞性肺疾病（COPD）加重期临床疗效。方法：选取2014年2月~2015年4月我院收治74例COPD加重期患者随机分为研究组和对照组，分别采用有创-无创序贯治疗和有创机械通气治疗，比较两组患者有创机械通气时间、机械通气总时间、住院时间、呼吸相关性肺炎（VAP）、再次插管及死亡发生率。结果：研究组患者有创机械通气时间、机械通气总时间、住院时间均少于对照组，比较差异有统计学意义（P＜0.05）。研究组患者VAP、再次插管及死亡发生率均低于对照组，比较差异有统计学意义（P＜0.05）。结论：有创-无创机械通气序贯治疗COPD加重期患者可缩短患者通气时间，降低并发症发生率，提高治疗效果。“,”Objective Discussion Invasive - Noninvasive Ventilation sequential treatment of chronic obstructive pulmonary disease (COPD) exacerbation of clinical efficacy.Method Select the February 2014 ~ April 2015 in our hospital 74 cases of exacerbation of COPD were randomly divided into study group, invasive - noninvasive sequential therapy and invasive mechanical ventilation, two groups were compared with invasive mechanical ventilation time, respiratory-associated pneumonia (VAP), the incidence of re-intubation and death. Result Study group of patients with invasive mechanical ventilation time, the difference was statistically significant (P <0.05). VAP patient study group, the difference was statistically significant (P <0.05).Conclusion Invasive - Noninvasive Ventilation sequential therapy in patients with exacerbation of COPD patient ventilation may shorten the time and reduce the incidence of complications.