Objective:To evaluate the clinical effect of scraping therapy in the treatment of perimenopausal syn-drome (PMS).Methods:Thirty recruited PMS subjects were treated with scraping therapy in the Outpatient Depart-ment,Acupuncture-Moxibustion Hospital,China Academy of Chinese Medical Sciences,at the areas in-cluding Shéntíng(神庭GV24)-Bǎihuì(百会GV20),Qìhǎi(气海CV6)-Guānyuán(关元CV4),Zǐgōng(子宫Ex-CA1),Zúsānlǐ(足三里ST36)-Xiàjùxū(下巨虚ST39),Dìjī(地机SP8)-Sányīnjiāo(三阴交SP6),Tàichōng(太冲LR3)-Xíngjiān(行间LR2),Gānshū(肝俞BL18)-Dǎnshū(胆俞BL19),Píshū(脾俞BL20)-Wèishū(胃俞BL 21),and Sānjiāoshū(三焦俞BL 22)-Shènshū(肾俞BL 23),with an even reinforcing-reducing method.Be-fore and after treatment,the serum follicle-stimulating hormone (FSH),luteinizing hormone (LH),and estradiol (E2) were tested.And before treatment and at the 4th week,8th week,and 12th week of treat-ment,the Kupperman index (KI) and menopause-specific quality of life questionnaire (MENQOL) symp-tom scores were recorded for evaluating the clinical efficacy.Results:Comparing with before treatment,the modified Kupperman symptom scores were all decreased after treatment,the difference was statistically significant (P＜0.05);all symptoms were relieved signifi-cantly after treatment,the difference was statistically significant (all P＜ 0.05).There was no significant difference in serum E2,FSH,and LH levels after treatment(all P＞0.05);the total effective rate was 85.71％after the 4 weeks\' treatment,96.42％ after the 8 weeks\' treatment,and 96.42％ after the 12 weeks\' treatment.Conclusion:Scraping therapy can relieve the PMS symptoms to some extent.It can improve the life qual-ity of PMS subjects.Its influence on the estrogen levels of PMS subjects was not obvious.