论文部分内容阅读
一些证据表明,免疫机理可能再与再障患者造血祖细胞的破坏或抑制。当从患者血中除去T—淋巴细胞后,可增加造血细胞集落形成。已证明再障患者血及骨髓中存在这种对造血细胞集落有抑制作用的淋巴细胞。作者测定了28例再障患者血中的T淋巴细胞。亚群辅助T细胞/诱导T细胞(OKT4+)与抑制T细胞/细胞毒T细胞(OKT7+)的平均比值,比值为1.24±0.74X±SD,明显低于正常人(1.78±0.57)和其它血液病患者(1.82±0.92)。53％的患者由于辅助T细胞/诱导T细胞对数减少。而抑制T细胞/细胞毒T细胞增加,比值倒置(≤1)。12例再障患者中7例HLA-DR显示增
There is some evidence that immune mechanisms may be associated with the destruction or inhibition of hematopoietic progenitor cells in patients with aplastic anemia. When T-lymphocytes are removed from the patient’s blood, hematopoietic colony formation can be increased. It has been demonstrated that there is a lymphocyte that inhibits hematopoietic colony in the blood and bone marrow of aplastic anemia patients. The authors measured T lymphocytes in 28 patients with aplastic anemia. The average ratio of OKT4 + to OKT7 + was 1.24 ± 0.74X ± SD, which was significantly lower than that of normal (1.78 ± 0.57) and other blood Patients (1.82 ± 0.92). Fifty-three percent of patients had reduced logarithm of helper T cells / induced T cells. While inhibiting T cell / cytotoxic T cells increased, the ratio of inversion (≤ 1). Seven of 12 patients with aplastic anemia showed increased HLA-DR