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为研究ｎｍ２３基因产物与肺癌临床病理间的关系，应用ＳＡＢＣ免疫组化染色法检测６９例肺癌标本中ｎｍ２３基因产物二磷酸核苷激酶（ＮＤＰＫ）的表达。结果表明，ｎｍ２３在肺癌中有较高表达，阳性率为７９．７％（５５／６９），其中鳞癌１００％（３１／３１），腺癌７１．４％（２０／２８）、小细胞癌４０％（４／１０），在鳞癌中的表达较腺癌及小细胞癌高（Ｐ＜０．０５）。ｎｍ２３的表达与肺鳞癌的分化程度无关（Ｐ＞０．０５）；与肺鳞癌、肺腺癌及其他癌有无肺门或纵隔淋巴结转移无关（Ｐ＞０．０５）。提示肺癌的形成与转移和多基因、多步骤的遗传学改变有关，应同时研究ｎｍ２３基因与其他因素，以准确反映肺癌恶性生物学行为的重要特点。
In order to study the relationship between the nm23 gene product and clinical pathology of lung cancer, the expression of the nm23 gene product nucleoside diphosphate kinase (NDPK) in 69 lung cancer specimens was detected by SABC immunohistochemical staining. The results showed that nm23 was highly expressed in lung cancer, with a positive rate of 79.7% (55/69), including 100% (31/31) of squamous cell carcinoma, 71.4% (20/28) of adenocarcinoma, and small cell Cancer 40% (4/10), higher in squamous cell carcinoma than adenocarcinoma and small cell carcinoma (P<0.05). The expression of nm23 was not related to the degree of differentiation of lung squamous cell carcinoma (P>0.05). It was not related to the presence of hilar or mediastinal lymph node metastasis in lung squamous cell carcinoma, lung adenocarcinoma, and other cancers (P>0.05). It is suggested that the formation and metastasis of lung cancer are related to the multi-gene and multi-step genetic changes. The nm23 gene and other factors should be studied at the same time to accurately reflect the important features of malignant biological behavior of lung cancer.