LIM only转录因子是LIM基因家族中的LIM only基因编码的转录调节因子 ,其蛋白 (LMO蛋白 )结构中含 1个或多个LIM结构域。LIM结构域由两个串联重复的种间高度保守的LIM基元组成。现已发现属于该家族的基因主要有LMO1、LMO2、LMO3、LMO4、dLMO、XLMO、PDLP、FHL等 ,并且还会有新的发现。迄今的研究结果表明 ,LMO蛋白是一种蛋白相互作用的适配器 ,它的LIM结构域可与核内广泛分布的LIM结构域结合蛋白或其他的转录调节因子结合形成转录复合体 ,启动特异基因的转录 ,调节生物的发育和分化 ,并与肿瘤的形成有关 The LIM only transcription factor is a transcriptional regulator encoded by the LIM only gene in the LIM gene family and contains one or more LIM domains in its protein (LMO protein) structure. The LIM domain consists of two tandemly repeated interspecies highly conserved LIM motifs. It has been found that belong to the family of genes mainly LMO1, LMO2, LMO3, LMO4, dLMO, XLMO, PDLP, FHL, etc., and there will be new discoveries. To date, studies have shown that the LMO protein is a protein-protein adapter whose LIM domain binds to a wide range of LIM domain-binding proteins or other transcriptional regulators in the nucleus to form transcriptional complexes that initiate specific genes Transcription, regulation of biological development and differentiation, and with the formation of the tumor