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目的检测活动期溃疡性结肠炎(UC)患者血脂,评估其临床意义。方法收集活动期UC患者的住院资料,选取139例活动期UC患者(UC组)和100例健康者(C组),分析两组血浆LDL-C、TG、HDL-C、TC、脂蛋白A和C反应蛋白(CRP)水平差异,评价活动期UC患者血脂异常与疾病严重程度的关系。结果与C组比较,UC组患者LDL-C、TG、HDL-C和TC水平降低(P<0.05)。重度UC患者的LDL-C、HDL-C和TC水平较轻度UC者降低(P<0.05),并与CRP呈负相关(P<0.05)。结论活动期UC患者胆固醇水平显著性降低,胆固醇水平可以反映UC患者的病情严重程度。
Objective To detect the serum lipids in patients with active ulcerative colitis (UC) and evaluate its clinical significance. Methods The hospitalization data of active UC patients were collected. One hundred and ninety-three active UC patients (UC group) and 100 healthy subjects (C group) were enrolled in this study. Plasma LDL-C, TG, HDL- And C-reactive protein (CRP) levels in patients with active UC to assess the relationship between dyslipidemia and the severity of the disease. Results Compared with group C, the levels of LDL-C, TG, HDL-C and TC in UC group decreased (P <0.05). The levels of LDL-C, HDL-C and TC in severe UC patients were lower than those in mild UC patients (P <0.05), and negatively correlated with CRP (P <0.05). Conclusion The level of cholesterol in active UC patients decreased significantly, and the level of cholesterol could reflect the severity of UC patients.