论文部分内容阅读
目的系统评价甘露糖结合凝集素2(mannose-binding lectin 2,MBL2)基因P57位点多态性与结核易感性的相关性。方法检索Pub Med、CNKI、Wan Fang Data、CBM、EMbase、VIP等数据库,检索时限为建库至2016年6月20日。查找所有研究MBL2基因P57位点多态性与结核易感性关系的相关文献,采用Rev Man 5.3软件进行Meta分析。结果共纳入8篇英文文献,均为病例对照研究,结核组共1 375例,对照组共1 465例。经异质性检验,各研究之间不存在统计学异质性(P≥0.1),故总体分析采用固定效应模型。Meta分析结果显示:在总体人群中,MBL2基因P57位点与结核易感性关联无统计学意义(CC+AC vs AA:OR=0.84,95%CI:0.68~1.04,P>0.05)。亚组分析结果显示:在亚洲人群中,MBL2基因P57位点多态性与结核易感性关联无统计学意义(CC+AC vs AA:OR=1.46,95%CI:0.82~2.60,P>0.05);在高加索人群中关联也无统计学意义(CC+AC vs AA:OR=0.80,95%CI:0.33~1.92,P>0.05);在非洲人群中,MBL2基因P57位点多态性可能降低结核易感性,结果有统计学意义(CC+AC vs AA:OR=0.77,95%CI:0.61~0.97,P<0.05)。结论MBL2基因P57位点多态性可能降低非洲人群结核发病风险,与亚洲人群和高加索人群结核的发病风险可能不存在相关性,但该研究样本量较小,需扩大样本量进一步确认。
Objective To evaluate the relationship between polymorphism of P57 locus of mannose-binding lectin 2 (MBL2) gene and the susceptibility to tuberculosis. Methods The databases of Pub Med, CNKI, Wan Fang Data, CBM, EMbase and VIP were searched, and the search time was up to June 20, 2016. To find out all the relevant literature about the relationship between P57 locus polymorphism of MBL2 gene and the susceptibility to tuberculosis, Meta-analysis was performed using Rev Man 5.3 software. Results A total of 8 English articles were included, all of which were case-control studies. There were 1 375 tuberculosis patients and 1 465 control subjects. The heterogeneity test, there is no statistical heterogeneity between the study (P ≥ 0.1), so the overall analysis using the fixed effect model. Meta-analysis showed that there was no significant correlation between MBL2 P57 locus and tuberculosis susceptibility in the general population (CC + AC vs AA: OR = 0.84, 95% CI: 0.68-1.04, P> 0.05). Subgroup analysis showed that there was no significant correlation between MBL2 P57 locus polymorphism and tuberculosis susceptibility in Asian population (CC + AC vs AA: OR = 1.46, 95% CI: 0.82-2.60, P> 0.05 ). There was no significant association in Caucasians (CC + AC vs. AA: OR = 0.80, 95% CI: 0.33-1.92, P> 0.05). In the African population, P57 locus polymorphism of MBL2 gene may be Reduce the susceptibility to tuberculosis, the results were statistically significant (CC + AC vs. AA: OR = 0.77, 95% CI: 0.61 to 0.97, P <0.05). Conclusion Polymorphism at P57 locus of MBL2 gene may reduce the risk of tuberculosis in African population, but may not be related to the risk of tuberculosis in Asian population and Caucasian population. However, the sample size of MBL2 gene is small and need to be further confirmed by expanding the sample size.