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原发性淀粉样变性和继发性淀粉样变性已熟为人知,它们是淀粉样蛋白过度生成的结果。最近,一种淀粉样变性的独特形式—骨淀粉样蛋白瘤(Amyloidomas of bone)作为长期血液透析的并发症被报道。它表现为腕管综合征、骨关节病、脊柱关节病和囊性骨病变(即淀粉样蛋白瘤),是因一种新发现的淀粉样蛋白—β_2微球蛋白排泄减少所致。这种新型蛋白为低分子量血清蛋白(在健康人的血清内、这种蛋白的量非常小。在血液透析接受者的血清内含量显著增加。不能被常规血液透析膜滤出)有在肌肉骨骼系统沉积的倾向。作者报告4例(女3例、男1例)血液透析所致的淀粉样蛋白瘤。年龄62～78岁,分别因慢性肾衰继发糖尿病性肾小球坏死;鹿角状结石双侧肾切除;常染色
Primary amyloidosis and secondary amyloidosis are well known as the result of the overproduction of amyloid. Recently, an amyloidomas of bone, a unique form of amyloidosis, has been reported as a complication of chronic hemodialysis. It manifests as carpal tunnel syndrome, osteoarthrosis, spondyloarthropathies and cystic bone lesions (ie, amyloidomas) due to a newly discovered decrease in amylin-β 2 microglobulin excretion. This novel protein is a low molecular weight serum protein (in very healthy human serum, this protein is very small in volume and has a significant increase in the serum content of hemodialysis recipients and can not be filtered out by conventional hemodialysis membranes) System deposition tendency. The authors report 4 cases (3 female, 1 male) hemodialysis caused by amyloidoma. Age 62 to 78 years old, respectively, due to chronic renal failure secondary to diabetic glomerular necrosis; antler bilateral bilateral nephrectomy; often stained